Cord Blood Cord Blood Diseases and Treatments

Question 1

Which form of childhood leukemia was one of the first diseases successfully treated with cord blood transplantation?

Accepted Answer

Acute lymphoblastic leukemia (ALL)

Answer

Chronic lymphocytic leukemia (CLL)

Answer

Hairy cell leukemia

Answer

Adult T-cell leukemia

Question 2

How does cord blood transplantation help patients with sickle cell disease?

Accepted Answer

It replaces the sickling red blood cells with donor-derived normal red blood cells

Answer

It corrects the gene directly in existing cells

Answer

It provides pain medications to manage crises

Answer

It removes the spleen to reduce complications

Question 3

What is beta-thalassemia major and how does cord blood transplantation address it?

Accepted Answer

A hemoglobin disorder caused by absent or reduced beta-globin production, cured by replacing defective stem cells with healthy donor cord blood

Answer

A platelet disorder treated with transfusion only

Answer

A clotting factor deficiency treated with infusions

Answer

A white blood cell cancer treated with chemotherapy only

Question 4

What is Fanconi anemia and why is cord blood transplantation preferred for its treatment?

Accepted Answer

An inherited bone marrow failure syndrome with DNA repair defects; cord blood is preferred due to its lower GVHD risk and tolerance of HLA mismatches

Answer

An acquired anemia treated with iron supplements; cord blood is not preferred

Answer

A nutritional deficiency; cord blood provides missing proteins

Answer

A viral infection cured by antivirals

Question 5

Which metabolic storage disorder affecting the brain is treated with cord blood transplantation to halt neurological progression?

Accepted Answer

Krabbe disease (globoid cell leukodystrophy)

Answer

Phenylketonuria (PKU)

Answer

Celiac disease

Answer

Wilson's disease

Question 6

What neurological condition has shown encouraging results in clinical trials using autologous cord blood infusion?

Accepted Answer

Cerebral palsy

Answer

Multiple sclerosis

Answer

Amyotrophic lateral sclerosis (ALS)

Answer

Alzheimer's disease