Cord Blood Cord Blood Stem Cells

Question 1

What type of stem cells are primarily found in cord blood that give rise to all blood and immune cells?

Accepted Answer

Hematopoietic stem cells

Answer

Embryonic stem cells

Answer

Induced pluripotent stem cells

Answer

Adipose-derived stem cells

Question 2

Which surface marker is most commonly used to identify and quantify hematopoietic stem cells in cord blood?

Accepted Answer

CD34+

Answer

CD3+

Answer

CD19+

Answer

CD56+

Question 3

Compared to bone marrow stem cells, cord blood stem cells have which key proliferative advantage?

Accepted Answer

Longer telomeres and higher self-renewal capacity

Answer

Shorter telomeres

Answer

Lower CD34+ concentration

Answer

Greater susceptibility to apoptosis

Question 4

What does 'engraftment' mean in the context of a cord blood transplant?

Accepted Answer

Successful establishment of donor stem cells in the recipient's bone marrow

Answer

Rejection of the donor cells by the recipient

Answer

Freezing of cord blood for storage

Answer

Removal of red blood cells from cord blood

Question 5

Why do cord blood T-cells cause less graft-versus-host disease compared to adult donor T-cells?

Accepted Answer

Cord blood T-cells are naive and less alloreactive

Answer

Cord blood has no T-cells

Answer

Cord blood T-cells produce more interferon-gamma

Answer

Cord blood T-cells are fully activated at birth

Question 6

Which colony-forming unit assay is used to assess the functional potency of hematopoietic progenitors in a cord blood unit?

Accepted Answer

CFU-GM assay

Answer

ELISA assay

Answer

PCR assay

Answer

Flow cytometry only