Cord Blood HLA Matching and Compatibility

Question 1

What does HLA stand for in the context of cord blood transplantation?

Accepted Answer

Human Leukocyte Antigen

Answer

Human Lymphocyte Association

Answer

Hematopoietic Leukocyte Antigen

Answer

Hemoglobin Leukocyte Antibody

Question 2

What is the minimum HLA match typically required for a cord blood unit to be considered for transplantation?

Accepted Answer

4/6 match

Answer

3/6 match

Answer

5/6 match

Answer

6/6 match

Question 3

On which chromosome is the major histocompatibility complex (MHC), which encodes HLA genes, located?

Accepted Answer

Chromosome 6

Answer

Chromosome 1

Answer

Chromosome 9

Answer

Chromosome 17

Question 4

What is the term for the set of HLA alleles inherited together as a unit from one parent?

Accepted Answer

Haplotype

Answer

Genotype

Answer

Phenotype

Answer

Karyotype

Question 5

Which HLA class presents intracellular peptides primarily to CD8+ cytotoxic T cells?

Accepted Answer

Class I (HLA-A, B, C)

Answer

Class II (HLA-DR, DQ, DP)

Answer

Class III

Answer

Both Class I and Class II equally

Question 6

What immune reaction occurs when donor T cells recognize and attack the recipient's tissues after cord blood transplantation?

Accepted Answer

Graft-versus-host disease (GvHD)

Answer

Host-versus-graft disease

Answer

Autoimmune hemolytic anemia

Answer

Hyperacute rejection

Question 7

Why does cord blood transplantation tolerate greater HLA mismatch compared to adult donor transplants?

Accepted Answer

Cord blood T cells are immunologically naive and less alloreactive

Answer

Cord blood contains no T cells

Answer

Cord blood is always from a related donor

Answer

Cord blood units contain higher total nucleated cell counts