CCTN Trivia 4

Question 1

Which immunosuppressant is associated with the development of post-transplant lymphoproliferative disorder (PTLD)?

Accepted Answer

Tacrolimus and overall high immunosuppression burden

Answer

PTLD is associated with high overall immunosuppression burden, particularly with EBV-driven B-cell proliferation; no single drug is solely responsible.

Question 2

What does 'cold ischemia time' refer to in organ transplantation?

Accepted Answer

Duration from donor cross-clamp to organ implantation reperfusion

Answer

Cold ischemia time is the period from donor organ cooling/cross-clamp to reperfusion in the recipient, and longer times increase ischemia-reperfusion injury.

Question 3

Which antifungal agent is commonly used for prophylaxis against Candida infections in liver transplant recipients?

Accepted Answer

Fluconazole

Answer

Fluconazole is the standard antifungal prophylaxis for Candida in liver transplant recipients during the early post-transplant period.

Question 4

A heart transplant patient presents with endomyocardial biopsy showing grade 2R rejection. This corresponds to which type of rejection?

Accepted Answer

Moderate acute cellular rejection

Answer

Grade 2R on the ISHLT scale represents moderate acute cellular rejection, typically requiring augmented immunosuppression.

Question 5

Which laboratory value is most specific for monitoring liver graft function in the immediate post-transplant period?

Accepted Answer

Prothrombin time/INR

Answer

The liver synthesizes clotting factors, so PT/INR reflects liver synthetic function and is a sensitive early marker of graft performance.

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN Trivia 4