CCTN Post-Transplant Immunosuppressive Medications

Question 1

Tacrolimus exerts its immunosuppressive effect by inhibiting which enzyme?

Accepted Answer

Calcineurin

Answer

mTOR

Answer

Inosine monophosphate dehydrogenase

Answer

Janus kinase

Question 2

Which side effect is most associated with long-term tacrolimus use in transplant recipients?

Accepted Answer

Hypertension and nephrotoxicity

Answer

Gingival hyperplasia

Answer

Peripheral neuropathy

Answer

Hepatotoxicity

Question 3

Mycophenolate mofetil (MMF) inhibits which enzyme to suppress lymphocyte proliferation?

Accepted Answer

Inosine monophosphate dehydrogenase (IMPDH)

Answer

Calcineurin

Answer

mTOR

Answer

Dihydrofolate reductase

Question 4

A transplant nurse notes a tacrolimus trough level of 22 ng/mL in a 3-month post-kidney-transplant patient. What is the most appropriate action?

Accepted Answer

Notify the provider because the level is supratherapeutic

Answer

Increase the dose because levels should be higher at 3 months

Answer

Document and continue current regimen

Answer

Administer a supplemental dose immediately

Question 5

Which immunosuppressant is an mTOR inhibitor used in transplantation?

Accepted Answer

Sirolimus

Answer

Cyclosporine

Answer

Azathioprine

Answer

Basiliximab

Question 6

Which medication is used as induction therapy in transplantation and works by depleting T lymphocytes?

Accepted Answer

Anti-thymocyte globulin (ATG)

Answer

Mycophenolate mofetil

Answer

Tacrolimus

Answer

Prednisone