CCTN Transplant Immunology and Rejection

Question 1

Which type of rejection occurs within minutes to hours after transplantation and is caused by preformed antibodies?

Accepted Answer

Hyperacute rejection

Answer

Acute cellular rejection

Answer

Chronic rejection

Answer

Accelerated acute rejection

Question 2

What is the primary role of HLA matching in solid organ transplantation?

Accepted Answer

To reduce the risk of immunologic rejection

Answer

To determine organ size compatibility

Answer

To match blood types between donor and recipient

Answer

To assess organ function prior to transplant

Question 3

Acute cellular rejection is primarily mediated by which immune cells?

Accepted Answer

T lymphocytes

Answer

B lymphocytes

Answer

Natural killer cells

Answer

Neutrophils

Question 4

Which immunologic test is performed before transplantation to detect preformed donor-specific antibodies?

Accepted Answer

Cross-match test

Answer

Complement fixation test

Answer

Western blot

Answer

ELISA for ANA

Question 5

Chronic allograft nephropathy is characterized by which pathological finding on biopsy?

Accepted Answer

Interstitial fibrosis and tubular atrophy

Answer

Neutrophilic infiltration

Answer

Hyperacute vascular thrombosis

Answer

Granulomatous inflammation

Question 6

Panel Reactive Antibody (PRA) levels above what percentage indicate a highly sensitized transplant candidate?

Accepted Answer

80%

Answer

20%

Answer

50%

Answer

10%