CCTN Trivia 3

Question 1

Which viral infection is the most common opportunistic infection in solid organ transplant recipients?

Accepted Answer

Cytomegalovirus (CMV)

Answer

CMV is the most prevalent opportunistic viral infection post-transplant due to immunosuppression, often presenting 1–3 months after transplant.

Question 2

What is the primary risk associated with a CMV-negative recipient receiving an organ from a CMV-positive donor?

Accepted Answer

Primary CMV infection leading to CMV disease

Answer

A D+/R- mismatch places the recipient at highest risk for primary CMV disease because they lack prior immunity.

Question 3

Mycophenolate mofetil (MMF) works primarily by inhibiting which enzyme?

Accepted Answer

Inosine monophosphate dehydrogenase (IMPDH)

Answer

MMF inhibits IMPDH, blocking de novo purine synthesis and selectively suppressing lymphocyte proliferation.

Question 4

Which organism causes PCP (Pneumocystis pneumonia) in immunocompromised transplant patients?

Accepted Answer

Pneumocystis jirovecii

Answer

Pneumocystis jirovecii (formerly P. carinii) causes PCP, a serious fungal pneumonia requiring TMP-SMX prophylaxis post-transplant.

Question 5

What is the most common cause of late graft loss in kidney transplant recipients beyond the first year?

Accepted Answer

Chronic allograft nephropathy

Answer

Chronic allograft nephropathy, now often called interstitial fibrosis/tubular atrophy, is the leading cause of late kidney graft failure.

CCTN - Certified Clinical Transplant Nurse Practice Test