CCTN Trivia 2

Question 1

Which immunosuppressant drug class works by blocking calcineurin to prevent T-cell activation?

Accepted Answer

Calcineurin inhibitors

Answer

Calcineurin inhibitors such as tacrolimus and cyclosporine block calcineurin, preventing IL-2 production and T-cell proliferation.

Question 2

What is the primary purpose of the UNOS (United Network for Organ Sharing)?

Accepted Answer

Managing the national organ transplant system and waitlist

Answer

UNOS manages the national organ transplant system under contract with HRSA, maintaining the waitlist and matching policies.

Question 3

A liver transplant recipient develops new-onset hypertension and nephrotoxicity. Which immunosuppressant is most likely responsible?

Accepted Answer

Tacrolimus

Answer

Tacrolimus (a calcineurin inhibitor) is a common cause of nephrotoxicity and hypertension in transplant recipients.

Question 4

What does the term 'crossmatch' refer to in transplantation?

Accepted Answer

Testing recipient serum against donor lymphocytes for preformed antibodies

Answer

A crossmatch tests whether recipient serum contains antibodies that react against donor cells, predicting hyperacute rejection risk.

Question 5

Which type of rejection occurs within minutes to hours after transplantation due to preformed antibodies?

Accepted Answer

Hyperacute rejection

Answer

Hyperacute rejection is mediated by preformed recipient antibodies against donor antigens and occurs immediately after perfusion.

CCTN - Certified Clinical Transplant Nurse Practice Test