CCTN Certified Clinical Transplant Nurse 4

Question 1

Which of the following best describes 'hyperacute rejection' in solid organ transplantation?

Accepted Answer

Pre-formed recipient antibodies cause graft thrombosis within minutes to hours of reperfusion

Answer

Hyperacute rejection is caused by pre-formed donor-specific antibodies that bind immediately upon reperfusion, activating complement and causing microvascular thrombosis.

Question 2

A transplant recipient is prescribed trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis. The PRIMARY indication for this medication in this population is:

Accepted Answer

Prophylaxis against Pneumocystis jirovecii pneumonia (PCP)

Answer

TMP-SMX is the drug of choice for Pneumocystis jirovecii pneumonia prophylaxis in immunosuppressed transplant recipients, typically given for 6-12 months post-transplant.

Question 3

A patient awaiting a heart transplant has blood type O negative. This patient can receive a heart from:

Accepted Answer

O negative and O positive donors only

Answer

Blood type O is the universal donor for red cells, but for solid organs ABO compatibility (not exact match) is required; O recipients can receive from O+ or O- donors.

Question 4

Which of the following is an absolute contraindication to living kidney donation?

Accepted Answer

Active malignancy with metastatic disease

Answer

Active malignancy, particularly with metastatic potential, is an absolute contraindication to living donation due to the risk of transmitting cancer to the immunosuppressed recipient.

Question 5

Sirolimus (rapamycin) differs from tacrolimus in its mechanism of action by:

Accepted Answer

Inhibiting mTOR signaling to block T-cell proliferation

Answer

Sirolimus inhibits the mammalian target of rapamycin (mTOR), blocking cytokine-driven T-cell proliferation at the G1-to-S phase transition.

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN Certified Clinical Transplant Nurse 4