CCTN Transplant Immunology and Rejection

Question 1

Which type of rejection occurs within minutes to hours after transplantation and is caused by preformed antibodies?

Accepted Answer

Hyperacute rejection

Answer

Hyperacute rejection occurs within minutes to hours due to preformed recipient antibodies against donor antigens, causing immediate graft failure.

Question 2

What is the primary role of HLA matching in solid organ transplantation?

Accepted Answer

To reduce the risk of immunologic rejection

Answer

HLA matching reduces the immunologic mismatch between donor and recipient, thereby lowering the risk of rejection.

Question 3

Acute cellular rejection is primarily mediated by which immune cells?

Accepted Answer

T lymphocytes

Answer

Acute cellular rejection is primarily mediated by T lymphocytes that recognize donor antigens and mount an immune response against the graft.

Question 4

Which immunologic test is performed before transplantation to detect preformed donor-specific antibodies?

Accepted Answer

Cross-match test

Answer

The cross-match test mixes recipient serum with donor lymphocytes to detect preformed donor-specific antibodies that could cause rejection.

Question 5

Chronic allograft nephropathy is characterized by which pathological finding on biopsy?

Accepted Answer

Interstitial fibrosis and tubular atrophy

Answer

Chronic allograft nephropathy is characterized by interstitial fibrosis and tubular atrophy, reflecting cumulative immune and non-immune injury over time.

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN - Certified Clinical Transplant Nurse Practice Test

CCTN Transplant Immunology and Rejection