AOCNP Advanced Oncology Certified Nurse Practitioner 5

Question 1

A patient undergoing radiation to the mediastinum is at risk for which long-term cardiac complication?

Accepted Answer

Constrictive pericarditis and coronary artery disease

Answer

Mediastinal radiation can cause constrictive pericarditis, coronary artery disease, valvular disease, and cardiomyopathy as late complications.

Question 2

Which biomarker is most useful for monitoring response to therapy in patients with hepatocellular carcinoma?

Accepted Answer

Alpha-fetoprotein (AFP)

Answer

Alpha-fetoprotein (AFP) is the primary tumor marker used to monitor treatment response and surveillance in hepatocellular carcinoma.

Question 3

A patient with breast cancer develops brain metastases with significant vasogenic edema and headache. What is the initial pharmacologic management?

Accepted Answer

Dexamethasone

Answer

Dexamethasone is the first-line treatment for vasogenic edema from brain metastases, rapidly reducing inflammation and cerebral swelling.

Question 4

What is the recommended duration of anticoagulation for cancer-associated venous thromboembolism (VTE)?

Accepted Answer

At least 6 months with continuation as long as cancer is active

Answer

Guidelines recommend at least 6 months of anticoagulation for cancer-associated VTE, with continuation as long as the cancer remains active or treatment is ongoing.

Question 5

A patient with multiple myeloma develops hypercalcemia of malignancy. Which mechanism is primarily responsible?

Accepted Answer

Osteoclast activation by RANKL overexpression from myeloma cells

Answer

Myeloma cells overexpress RANKL and other osteoclast-activating factors, leading to osteolytic bone destruction and calcium release into the bloodstream.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Advanced Oncology Certified Nurse Practitioner 5