AOCNP Advance Oncology Nursing 4

Question 1

A patient with cervical cancer is receiving concurrent cisplatin and radiation therapy. She reports decreased urine output and her creatinine has risen from 0.9 to 2.4 mg/dL. The BEST immediate intervention is:

Accepted Answer

Hold cisplatin, ensure aggressive IV hydration, and consult nephrology

Answer

Acute cisplatin nephrotoxicity requires immediate drug hold, aggressive IV hydration to restore renal perfusion, and nephrology consultation.

Question 2

Which test result is REQUIRED before initiating treatment with PARP inhibitors (e.g., olaparib) in ovarian cancer?

Accepted Answer

BRCA1/BRCA2 germline or somatic mutation testing

Answer

PARP inhibitors exploit homologous recombination deficiency; BRCA1/2 mutation status determines eligibility and expected magnitude of benefit.

Question 3

An oncology NP is caring for a patient who develops stridor, facial swelling, and hypotension within 10 minutes of starting a paclitaxel infusion. The FIRST intervention is:

Accepted Answer

Stop the infusion immediately and administer epinephrine 0.3 mg IM

Answer

These signs indicate anaphylaxis; the infusion must be stopped immediately and epinephrine 0.3 mg IM administered as the first-line life-saving intervention.

Question 4

A patient with diffuse large B-cell lymphoma on R-CHOP develops a fever of 38.5°C on day 10 post-chemotherapy with an ANC of 200 cells/µL. According to MASCC criteria, what is the PRIORITY action?

Accepted Answer

Order blood cultures and begin empiric broad-spectrum IV antibiotics within 1 hour

Answer

Febrile neutropenia (ANC <500 with fever ≥38.3°C) requires blood cultures and empiric broad-spectrum IV antibiotics within 60 minutes of presentation.

Question 5

Which dietary modification is MOST important to counsel a patient receiving warfarin for cancer-associated thrombosis?

Accepted Answer

Maintain consistent vitamin K intake rather than eliminating it

Answer

Patients on warfarin should maintain consistent, not zero, vitamin K intake because dramatic fluctuations destabilize INR more than a steady moderate intake.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Advance Oncology Nursing 4