AOCNP Advance Oncology Nursing 3

Question 1

A patient undergoing allogeneic hematopoietic stem cell transplant develops a diffuse erythematous rash, diarrhea, and elevated bilirubin on day 25. What condition is MOST likely?

Accepted Answer

Acute graft-versus-host disease (aGVHD)

Answer

Rash, diarrhea, and liver dysfunction appearing within 100 days post-allogeneic SCT are the classic triad of acute graft-versus-host disease.

Question 2

Which of the following best describes the mechanism of action of trastuzumab (Herceptin)?

Accepted Answer

It binds HER2 receptors and inhibits downstream PI3K/Akt signaling

Answer

Trastuzumab is a monoclonal antibody that binds the extracellular domain of HER2, inhibiting HER2-mediated signaling and promoting antibody-dependent cellular cytotoxicity.

Question 3

An oncology NP reviews a patient's opioid regimen and calculates a total daily oral morphine equivalent of 320 mg. The patient reports moderate breakthrough pain every 2 hours. What is the appropriate breakthrough dose range?

Accepted Answer

10–15% of total daily dose (32–48 mg) every 1–4 hours as needed

Answer

Breakthrough opioid doses are typically 10–15% of the total daily opioid dose, administered every 1–4 hours as needed for acute pain flares.

Question 4

Which lab finding is MOST indicative of tumor lysis syndrome (TLS) requiring immediate intervention?

Accepted Answer

Serum potassium 6.8 mEq/L with peaked T-waves on ECG

Answer

Hyperkalemia with ECG changes (peaked T-waves) in TLS indicates life-threatening cardiac risk requiring emergency treatment.

Question 5

A patient receiving FOLFOX for colorectal cancer reports cold-induced paresthesias when touching cold surfaces. This is MOST characteristic of toxicity from which agent in the regimen?

Accepted Answer

Oxaliplatin

Answer

Cold-induced dysesthesia and paresthesias are hallmark acute neurotoxicity symptoms of oxaliplatin, distinct from the cumulative peripheral neuropathy it also causes.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Advance Oncology Nursing 3