AOCNP Cancer Screening and Prevention

Question 1

At what age does the USPSTF recommend initiating annual low-dose CT (LDCT) screening for lung cancer in high-risk individuals?

Accepted Answer

50 years

Answer

The USPSTF (2021 update) recommends annual LDCT screening beginning at age 50 for adults with a 20-pack-year history who currently smoke or quit within the past 10 years.

Question 2

The HPV vaccine is most effective when administered:

Accepted Answer

Before sexual debut, ideally at age 11–12

Answer

HPV vaccination generates the highest immune response and provides complete protection when given before HPV exposure, which is why it is recommended at age 11–12.

Question 3

Which stool-based test detects blood AND altered DNA markers from colorectal neoplasms?

Accepted Answer

Cologuard (stool DNA test, sDNA-FIT)

Answer

Cologuard combines fecal immunochemical testing for hemoglobin with stool DNA markers (KRAS, NDRG4, BMP3 methylation) for higher sensitivity than either test alone.

Question 4

The BRCA1/2 mutation confers the highest lifetime risk for which two cancers?

Accepted Answer

Breast and ovarian cancer

Answer

BRCA1/2 mutations confer a lifetime breast cancer risk of 50–80% and ovarian cancer risk of 15–44%, with BRCA1 conferring the highest ovarian risk.

Question 5

Lynch syndrome increases lifetime risk of which cancer most significantly?

Accepted Answer

Colorectal cancer

Answer

Lynch syndrome (caused by MLH1, MSH2, MSH6, PMS2, EPCAM mutations) confers a 40–80% lifetime risk of colorectal cancer and 15–60% for endometrial cancer.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Cancer Screening and Prevention