AOCNP Cancer Screening and Early Detection

Question 1

According to current ONCC guidelines, which imaging modality is recommended for lung cancer screening in high-risk individuals?

Accepted Answer

Low-dose computed tomography (LDCT) annually

Answer

Low-dose CT (LDCT) of the chest is recommended annually for high-risk individuals (ages 50–80, 20 pack-year smoking history, current or former smoker who quit within 15 years) based on USPSTF and NCCN guidelines, as it significantly reduces lung cancer mortality.

Question 2

Which of the following tumor markers is most useful in the early detection and monitoring of ovarian cancer?

Accepted Answer

CA-125

Answer

CA-125 is the primary serum biomarker used in ovarian cancer detection and monitoring. While not recommended for population screening due to low specificity, it is valuable in high-risk patients and for monitoring response to treatment.

Question 3

The Bethesda System is used to classify results from which cancer screening test?

Accepted Answer

Pap smear (cervical cytology)

Answer

The Bethesda System provides standardized terminology for reporting cervical cytology (Pap smear) results, categorizing findings from normal to high-grade squamous intraepithelial lesions (HSIL), which guides clinical management.

Question 4

At what age does the American Cancer Society recommend initiating average-risk colorectal cancer screening?

Accepted Answer

45 years

Answer

The American Cancer Society updated its guideline in 2018 to recommend colorectal cancer screening beginning at age 45 for average-risk adults, lowered from the previous recommendation of 50 years, due to increasing rates in younger adults.

Question 5

Which genetic mutation significantly elevates the lifetime risk of breast and ovarian cancer, prompting enhanced surveillance protocols?

Accepted Answer

BRCA1/BRCA2

Answer

Pathogenic variants in BRCA1 and BRCA2 genes confer a lifetime breast cancer risk of 50–72% and ovarian cancer risk of 17–44%. Carriers require enhanced screening including annual MRI and mammography beginning at age 25–30.

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP - Advanced Oncology Certified Nurse Practitioner Practice Test

AOCNP Cancer Screening and Early Detection