AANP Study Guide 2026
Everything you need to pass the AANP exam in one place: the exam format, every topic to study, real practice questions with explanations, flashcards, and full-length practice tests. Free, no sign-up needed.
📋 AANP Exam Format at a Glance
📚 AANP Topics to Study (22)
✍️ Sample AANP Questions & Answers
1. Which SSRI has the longest half-life and is least likely to cause discontinuation syndrome?
Fluoxetine has a half-life of 2–6 days (with active metabolite norfluoxetine at 4–16 days), which effectively tapers itself and minimizes discontinuation symptoms.
2. What is the first-line treatment for mild-to-moderate acne vulgaris characterized by comedones and a few inflammatory papules?
Topical retinoids normalize follicular keratinization and benzoyl peroxide has antimicrobial properties; both are recommended as first-line agents for mild-to-moderate acne.
3. A patient with darkening, velvety, hyperpigmented skin in the axillae and neck creases most likely has which underlying condition?
Acanthosis nigricans is strongly associated with insulin resistance and hyperinsulinemia, which stimulate keratinocyte and fibroblast proliferation via IGF-1 receptors.
4. A patient presents with a target-like skin lesion with central blistering after starting a new antibiotic. What condition should be suspected?
Erythema multiforme is characterized by target lesions (three concentric zones) and is commonly triggered by HSV infection or medications such as sulfonamides and penicillins.
5. A pregnant woman at 28 weeks with no blood type antibodies has Rh-negative blood. What intervention is indicated?
Rh-negative women receive RhoGAM at 28 weeks and again within 72 hours of delivery to prevent sensitization that could cause hemolytic disease in future Rh-positive fetuses.
6. Which medication used for gout prevention requires monitoring for ocular toxicity, including retinal damage?
Hydroxychloroquine (used for RA and lupus, sometimes related to inflammatory arthritis) can deposit in the retina, causing irreversible retinopathy with prolonged use.