AANP Pharmacology 2

Question 1

Which opioid analgesic has active metabolites that can accumulate in renal failure, causing CNS toxicity?

Accepted Answer

Morphine

Answer

Fentanyl

Answer

Buprenorphine

Answer

Methadone

Question 2

A nurse practitioner prescribes trimethoprim-sulfamethoxazole to a patient on methotrexate. What serious risk exists?

Accepted Answer

Bone marrow suppression and pancytopenia

Answer

Serotonin syndrome

Answer

QT prolongation

Answer

Hepatotoxicity only

Question 3

What is the antidote for acetaminophen overdose?

Accepted Answer

N-acetylcysteine

Answer

Naloxone

Answer

Flumazenil

Answer

Activated charcoal alone

Question 4

Which SSRI has the longest half-life and is least likely to cause discontinuation syndrome?

Accepted Answer

Fluoxetine

Answer

Paroxetine

Answer

Sertraline

Answer

Citalopram

Question 5

A patient prescribed a fluoroquinolone antibiotic reports new-onset tendon pain. What should the NP do?

Accepted Answer

Discontinue the fluoroquinolone and switch to an alternative antibiotic

Answer

Continue the antibiotic and add NSAIDs for pain

Answer

Reduce the dose and monitor

Answer

Order an MRI before any medication change

Question 6

Which medication is most appropriate for smoking cessation in a patient with a history of seizures?

Accepted Answer

Varenicline

Answer

Bupropion

Answer

Nicotine patch

Answer

Clonidine