According to Melzack and Wall's gate-control theory of pain, which of the following mechanisms is responsible for modulating the sensation of pain?
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A
The complete blockage of all sensory signals at the site of injury.
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B
The interaction between large and small nerve fibers in the spinal cord which can inhibit or facilitate pain signals to the brain.
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C
The release of endogenous opioids in the brain which universally dampens all incoming pain signals.
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D
The cognitive appraisal of the painful stimulus, which occurs exclusively in the prefrontal cortex.