MPharm Master of Pharmacy Master of Pharmacy: Research and Biostatistics 2

Question 1

In a randomized controlled trial, what does 'allocation concealment' prevent?

Accepted Answer

Selection bias during participant assignment

Answer

Allocation concealment prevents selection bias by ensuring the investigator cannot predict or influence which group a participant is assigned to before enrollment.

Question 2

A 95% confidence interval for a drug's mean reduction in blood pressure is (8 mmHg, 14 mmHg). What is the correct interpretation?

Accepted Answer

We are 95% confident the true population mean reduction falls between 8 and 14 mmHg

Answer

A 95% CI means that if the study were repeated many times, 95% of such intervals would contain the true population parameter.

Question 3

Which study design provides the strongest evidence for causal inference in pharmaceutical research?

Accepted Answer

Double-blind randomized controlled trial

Answer

A double-blind RCT controls for both selection bias and performance/detection bias, providing the highest level of evidence for causality.

Question 4

The Kaplan-Meier method is specifically used to analyze which type of data?

Accepted Answer

Time-to-event (survival) data with censored observations

Answer

Kaplan-Meier analysis estimates survival functions from time-to-event data, properly accounting for censored observations.

Question 5

In pharmacokinetic research, a two-compartment model assumes drug distributes between which compartments?

Accepted Answer

Central (plasma) and peripheral (tissue) compartments

Answer

A two-compartment model describes drug distribution between a central (blood/plasma) compartment and a peripheral (tissue) compartment with different rate constants.

MPharm Master of Pharmacy Practice Test

MPharm Master of Pharmacy Practice Test

MPharm Master of Pharmacy Master of Pharmacy: Research and Biostatistics 2