MPharm Master of Pharmacy Cheat Sheet 2026

The 30 highest-yield MPharm Master of Pharmacy facts, distilled from real exam questions. Print it, save it as a PDF, or study it here — free, no sign-up.

1. Which of these medications is a good alternative for the treatment of gonorrhea? → Ceftriaxone
2. Is it possible to determine the acidity strength of an acid solely based on its pKa value? → No, you need additional information.
3. Which rheological property of a gel formulation is described by the term 'thixotropy'? → Time-dependent reversible decrease in viscosity upon shearing, recovering at rest
4. What is the primary purpose of the Lipinski Rule of Five in drug design? → Predict oral bioavailability based on physicochemical properties
5. In the context of prodrug design, which enzyme is responsible for hydrolysis of ester prodrugs in the GI tract and plasma? → Esterases (carboxylesterases)
6. Which functional group undergoes Phase II glucuronidation conjugation in drug metabolism? → Hydroxyl, carboxyl, amino, and thiol groups
7. In the preparation of microspheres by solvent evaporation, which method is used when the drug is dissolved in the polymer solution? → Single emulsion (O/W) solvent evaporation
8. Which parameter in the Noyes-Whitney equation directly describes the rate of drug dissolution? → Surface area of the dissolving solid
9. What legal concept defines the maximum period within which a crime can be prosecuted? → Statute of limitations
10. What type of model describes physical laws of nature as not variable and not dependent on probability? → Deterministic Model
11. In a drug therapy problem (DTP) framework used by clinical pharmacists, which category describes a patient needing additional medication? → Needs additional drug therapy
12. True lubricants reduce the force needed to eject a tablet by lowering the force left in the die wall. → FALSE
13. What is the mechanism of action of colchicine, a plant-derived drug used for gout? → Binds tubulin and inhibits microtubule polymerization to reduce neutrophil migration
14. Reserpine, derived from Rauwolfia serpentina, lowers blood pressure by which mechanism? → Depletion of catecholamines from storage vesicles in adrenergic neurons
15. For which of the following medicines does pyridoxine work as an effective countermeasure? → Isoniazid
16. What would be the volume of distribution (Vd) for a drug that remains exclusively within the vascular compartment? → Low
17. Medications that are attached to albumin lack activity. → TRUE
18. What is the purpose of the 'pore former' component added to ethylcellulose membrane coatings on pellets? → To dissolve and create micropores that control drug permeation
19. Which property of a drug is described by the term 'metabolic stability'? → The rate at which a drug is metabolized by hepatic enzymes
20. The drug physostigmine is derived from the Calabar bean (Physostigma venenosum) and acts as: → A reversible acetylcholinesterase inhibitor
21. What difficulty is encountered by laboratories involved in pharmaceutical quality control? → Achieving maximum throughput with routine equipment
22. Which one among the options is excluded from the category of practitioners as defined by the Controlled Substance Act? → Hospital
23. A patient with atrial fibrillation and CrCl of 40 mL/min needs anticoagulation. Which DOAC requires the most significant dose reduction? → Dabigatran
24. Which renal function metric is most important for dose adjustment recommendations in clinical pharmacy? → Estimated GFR (eGFR)
25. What kind of macromolecules will a ligand (usually) bind to without making a chemical bond? → DNA, enzymes, receptors
26. What is the purpose of a process designed to discover the truth? → Research
27. Which in vitro dissolution test apparatus is most appropriate for evaluating drug release from transdermal patches? → USP Apparatus 5 (paddle over disk)
28. Which of these vitamins deficiencies causes pernicious anemia? → Vitamin B12
29. All of these drugs for high blood pressure are safe during pregnancy, except for which one? → Ramipril
30. A clinical pharmacist identifies a patient on lisinopril who develops a persistent dry cough. What is the recommended intervention? → Switch to an ARB such as losartan