MPharm Master of Pharmacy Master of Pharmacy: Pharmaceutical Technology and Drug Delivery Systems

Question 1

Which parameter in the Noyes-Whitney equation directly describes the rate of drug dissolution?

Accepted Answer

Surface area of the dissolving solid

Answer

Partition coefficient

Answer

Henderson-Hasselbalch ratio

Answer

Renal clearance

Question 2

In liposomal drug delivery, what is the term for liposomes engineered to avoid rapid clearance by the mononuclear phagocyte system?

Accepted Answer

Stealth liposomes

Answer

Cationic liposomes

Answer

Multilamellar vesicles

Answer

Niosomes

Question 3

Which type of controlled-release mechanism relies on osmotic pressure to drive drug release at a constant rate?

Accepted Answer

Elementary osmotic pump (OROS)

Answer

Matrix diffusion system

Answer

Reservoir membrane system

Answer

Ion-exchange resin complex

Question 4

What is the primary purpose of using a plasticizer in film-coating of tablets?

Accepted Answer

To improve flexibility and reduce brittleness of the coating film

Answer

To increase the melting point of the polymer

Answer

To reduce film permeability to moisture

Answer

To enhance drug solubility in the core

Question 5

Which emulsification theory explains stabilization of emulsions by the formation of a monomolecular film at the oil-water interface?

Accepted Answer

Interfacial film theory

Answer

Oriented wedge theory

Answer

Repulsion theory

Answer

Phase volume ratio theory

Question 6

In solid lipid nanoparticles (SLNs), which characteristic distinguishes them from conventional lipid emulsions?

Accepted Answer

The lipid core is solid at body temperature

Answer

They contain liquid lipids instead of solid lipids

Answer

They are larger than 10 micrometers

Answer

They cannot incorporate lipophilic drugs

Question 7

What does a drug's HLB (Hydrophilic-Lipophilic Balance) value of 4 indicate about its primary use?

Accepted Answer

Suitable as a water-in-oil (W/O) emulsifier

Answer

Suitable as a solubilizing agent for injectable formulations

Answer

Appropriate as a wetting agent

Answer

Appropriate as an oil-in-water (O/W) emulsifier