A patient with rheumatoid arthritis on methotrexate and naproxen develops toxicity. Which pharmacokinetic interaction is responsible?
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A
NSAIDs induce CYP3A4, increasing methotrexate metabolism
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B
NSAIDs reduce renal blood flow and tubular secretion, impairing methotrexate clearance
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C
Naproxen displaces methotrexate from DHFR binding sites
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D
NSAIDs increase methotrexate absorption via gut inflammation