In a patient with Parkinson's disease, which mechanism explains levodopa-induced dyskinesias after long-term use?
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A
Upregulation of dopamine D2 receptors in the caudate
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B
Pulsatile dopaminergic stimulation causing sensitization of striatal neurons
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C
Accumulation of dopamine metabolites causing oxidative stress
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D
Downregulation of dopamine transporters in the nigrostriatal pathway