MPharm Master of Pharmacy Master of Pharmacy: Pharmaceutical Formulations and Dosage Forms 4

Question 1

Which inhalation device generates particles through vibration of a liquid droplet mesh or membrane, requiring no propellant?

Accepted Answer

Soft mist inhaler (SMI) / vibrating mesh nebulizer

Answer

Vibrating mesh nebulizers use a piezoelectric-driven mesh with thousands of apertures to produce a fine aerosol without propellants or compressed air.

Question 2

For ophthalmic solutions, which tonicity value (mOsmol/kg) is considered isotonic with lacrimal fluid?

Accepted Answer

308 mOsmol/kg

Answer

Lacrimal fluid is isotonic at approximately 308 mOsmol/kg (equivalent to 0.9% NaCl), and ophthalmic formulations are adjusted to this tonicity to minimize irritation.

Question 3

In freeze-drying (lyophilization), the primary drying stage removes water by:

Accepted Answer

Sublimation of ice under vacuum below the product's collapse temperature

Answer

Primary drying sublimates frozen water directly to vapor under low pressure, bypassing the liquid phase, while maintaining the product below its collapse temperature.

Question 4

Which parameter describes the fraction of a drug dose absorbed from a solid oral dosage form relative to an IV dose?

Accepted Answer

Absolute bioavailability (F)

Answer

Absolute bioavailability (F) is calculated as (AUC_oral/AUC_IV) × (Dose_IV/Dose_oral), reflecting the fraction of drug that reaches systemic circulation.

Question 5

Capping and lamination defects during tablet compression are most often caused by:

Accepted Answer

Air entrapment in the die and excessive compression speed or elastic recovery

Answer

Capping occurs when entrapped air or high elastic recovery causes the top or bottom cap to separate from the tablet body after ejection.

MPharm Master of Pharmacy Practice Test

MPharm Master of Pharmacy Practice Test

MPharm Master of Pharmacy Master of Pharmacy: Pharmaceutical Formulations and Dosage Forms 4