MPharm Master of Pharmacy Clinical Pharmacy and Patient Care 2

Question 1

Which antidiabetic drug class carries the highest risk of hypoglycemia when used as monotherapy?

Accepted Answer

Sulfonylureas

Answer

Sulfonylureas stimulate insulin secretion independent of glucose levels, making hypoglycemia a primary adverse effect.

Question 2

A clinical pharmacist identifies a patient on lisinopril who develops a persistent dry cough. What is the recommended intervention?

Accepted Answer

Switch to an ARB such as losartan

Answer

ACE inhibitor-induced cough is a class effect due to bradykinin accumulation; switching to an ARB eliminates this side effect.

Question 3

Which renal function metric is most important for dose adjustment recommendations in clinical pharmacy?

Accepted Answer

Estimated GFR (eGFR)

Answer

eGFR quantifies kidney filtration capacity and is the standard basis for renal dose adjustments of renally cleared drugs.

Question 4

A patient with atrial fibrillation and CrCl of 40 mL/min needs anticoagulation. Which DOAC requires the most significant dose reduction?

Accepted Answer

Dabigatran

Answer

Dabigatran is approximately 80% renally eliminated and requires significant dose reduction or avoidance at CrCl < 50 mL/min.

Question 5

What is the purpose of a pharmacist-conducted medication reconciliation at hospital admission?

Accepted Answer

Create a complete and accurate list of current medications to prevent discrepancies

Answer

Medication reconciliation compares the patient's home medication list to admission orders to prevent omissions, duplications, and errors.

MPharm Master of Pharmacy Practice Test