HRT HRT for Male Patients (Testosterone Therapy) 2

Question 1

Testosterone aromatizes to estradiol in peripheral tissues. Which enzyme performs this conversion?

Accepted Answer

Aromatase (CYP19A1)

Answer

Aromatase (CYP19A1) converts androgens including testosterone to estrogens in peripheral tissues such as adipose, liver, and brain.

Question 2

Excessive estradiol levels in men on TRT can cause which side effect?

Accepted Answer

Gynecomastia and water retention

Answer

Excess estradiol from testosterone aromatization stimulates breast gland tissue causing gynecomastia and promotes renal sodium and water retention.

Question 3

Which drug class is used to reduce estradiol levels in men on TRT who develop symptoms of estrogen excess?

Accepted Answer

Aromatase inhibitors (e.g., anastrozole)

Answer

Aromatase inhibitors block the conversion of testosterone to estradiol, lowering serum estrogen in men who develop gynecomastia or other estrogen excess symptoms during TRT.

Question 4

Prior to initiating TRT, a digital rectal exam (DRE) and PSA test are required to screen for which condition?

Accepted Answer

Prostate cancer

Answer

Testosterone stimulates prostate tissue, so undetected prostate cancer could be accelerated by TRT; DRE and PSA baseline screening are mandatory before initiation.

Question 5

How does obstructive sleep apnea (OSA) relate to testosterone therapy in men?

Accepted Answer

TRT can worsen OSA; sleep apnea should be treated or controlled before initiating TRT

Answer

Testosterone can stimulate upper airway muscle changes and erythrocytosis that worsen sleep apnea severity; uncontrolled OSA is a relative contraindication to TRT.

HRT - Hormone Replacement Therapy Certification Practice Test

HRT - Hormone Replacement Therapy Certification Practice Test

HRT HRT for Male Patients (Testosterone Therapy) 2