HRT HRT Delivery Methods & Administration

Question 1

Which HRT delivery method provides the most consistent serum hormone levels by bypassing first-pass hepatic metabolism?

Accepted Answer

Transdermal patch

Answer

Transdermal patches deliver hormones directly into the bloodstream, avoiding first-pass liver metabolism and producing more stable serum levels.

Question 2

What is the primary advantage of subcutaneous pellet implants over other HRT delivery methods?

Accepted Answer

Sustained hormone release over 3–6 months

Answer

Subcutaneous pellets slowly dissolve under the skin, releasing hormones consistently for 3–6 months without daily administration.

Question 3

When applying a transdermal estrogen gel, which site is MOST appropriate?

Accepted Answer

Upper arm or inner thigh

Answer

Transdermal estrogen gel should be applied to clean, dry skin on the upper arm or inner thigh, avoiding mucous membranes and breast tissue.

Question 4

Which route of progesterone administration is associated with the lowest risk of hepatic side effects?

Accepted Answer

Vaginal suppository

Answer

Vaginal progesterone bypasses hepatic first-pass metabolism, resulting in high uterine bioavailability with minimal systemic liver exposure.

Question 5

Intramuscular testosterone cypionate injections are typically administered at what interval for male HRT?

Accepted Answer

Every 1–2 weeks

Answer

Testosterone cypionate has a half-life that makes every 1–2 week IM injections the standard dosing interval for steady hormone levels.

HRT - Hormone Replacement Therapy Certification Practice Test