Free Master of Pharmacy: Pharmacology and Therapeutics Questions and Answers

Question 1

Hyperkalemia and a dry cough that won't go away are side effects of which of these drug classes?

Accepted Answer

ACE inhibitors

Answer

Angiotensin-converting enzyme (ACE) inhibitors are a class of medications commonly used to treat high blood pressure and heart failure. Two well-known side effects associated with ACE inhibitors are hyperkalemia (elevated potassium levels in the blood) and a persistent, dry cough, which occurs in a significant percentage of patients due to the accumulation of bradykinin.

Question 2

Which of these medications is a good alternative for the treatment of gonorrhea?

Accepted Answer

Ceftriaxone

Answer

Ceftriaxone is a third-generation cephalosporin antibiotic that is highly effective and widely recommended as a first-line treatment for gonorrhea, often in combination with azithromycin. It is a potent bactericidal agent that targets the bacterial cell wall, making it a reliable choice for combating this sexually transmitted infection.

Question 3

Which of these vitamins deficiencies causes pernicious anemia?

Accepted Answer

Vitamin B12

Answer

Pernicious anemia is a type of megaloblastic anemia caused by a deficiency in Vitamin B12 (cobalamin). This deficiency typically arises from an inability to absorb B12 due to a lack of intrinsic factor, which is necessary for its absorption in the small intestine, leading to impaired red blood cell production.

Question 4

What kind of drug toxicity causes the level of N-acetyl-p-benzoquinone imine to rise?

Accepted Answer

Acetaminophen

Answer

Acetaminophen (paracetamol) overdose leads to the accumulation of a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI). Normally, NAPQI is detoxified by glutathione, but in overdose, glutathione stores are depleted, allowing NAPQI to bind to liver cells and cause severe hepatotoxicity.

Question 5

Which of the following is a drug that blocks the proteasome?

Accepted Answer

Bortezomib

Answer

Bortezomib is a proteasome inhibitor, a type of anticancer drug used primarily in the treatment of multiple myeloma and mantle cell lymphoma. It works by reversibly inhibiting the 26S proteasome, a protein complex that degrades ubiquitinated proteins, leading to the accumulation of misfolded proteins and induction of apoptosis in cancer cells.

MPharm Master of Pharmacy Practice Test

MPharm Master of Pharmacy Practice Test

Free Master of Pharmacy: Pharmacology and Therapeutics Questions and Answers