FPGEE Trivia FPGEE Exam 3 — Questions and Answers
Question 1: Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged?
- Volume of distribution
- Clearance
- Bioavailability (Correct answer)
- Half-life
Correct answer: Bioavailability
Bioavailability (F) represents the fraction of the administered dose that reaches systemic circulation.
Question 2: A patient with a penicillin allergy (anaphylaxis) requires antibiotic therapy for MRSA. Which agent is most appropriate?
- Ampicillin
- Cefazolin
- Vancomycin (Correct answer)
- Amoxicillin-clavulanate
Correct answer: Vancomycin
Vancomycin is the drug of choice for MRSA and does not cross-react with penicillins.
Question 3: Which pregnancy category (FDA legacy system) was associated with demonstrated fetal risk in human studies?
- Category A
- Category B
- Category C
- Category D (Correct answer)
Correct answer: Category D
Category D indicates evidence of human fetal risk, but potential benefits may warrant use in serious situations.
Question 4: What is the antidote for acetaminophen overdose?
- Naloxone
- Flumazenil
- N-acetylcysteine (Correct answer)
- Activated charcoal alone
Correct answer: N-acetylcysteine
N-acetylcysteine replenishes glutathione stores, preventing hepatotoxicity from NAPQI accumulation.
Question 5: Which receptor type mediates the bronchodilatory effect of albuterol?
- Alpha-1 adrenergic
- Beta-1 adrenergic
- Beta-2 adrenergic (Correct answer)
- Muscarinic M3
Correct answer: Beta-2 adrenergic
Albuterol selectively activates beta-2 adrenergic receptors in bronchial smooth muscle to cause bronchodilation.
Question 6: What is the recommended maximum daily dose of acetaminophen for a healthy adult?
- 2,000 mg
- 3,000 mg
- 4,000 mg (Correct answer)
- 6,000 mg
Correct answer: 4,000 mg
The maximum daily dose of acetaminophen for healthy adults is 4,000 mg (4 g) per day.
Question 7: Which of the following antihypertensives is absolutely contraindicated in pregnancy due to teratogenicity?
- Labetalol
- Methyldopa
- Nifedipine
- ACE inhibitors (Correct answer)
Correct answer: ACE inhibitors
ACE inhibitors cause fetal renal damage and are absolutely contraindicated in pregnancy (all trimesters).
FPGEE Trivia FPGEE Exam 3
Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged?