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FPGEE Cheat Sheet 2026

The 30 highest-yield FPGEE facts, distilled from real exam questions. Print it, save it as a PDF, or study it here ā€” free, no sign-up.

200 questions
270 min time limit
75% to pass
  1. What is the correct needle gauge to use when administering a subcutaneous (SQ) injection to an average-weight adult? ā†’ 25ā€“27 gauge
  2. A drug information response recommends a lower dose for a patient with renal impairment. Which primary resource BEST supports this recommendation? ā†’ Lexicomp Renal Disease Dosing or the FDA package insert renal dosing section
  3. A 65-year-old patient requires a loading dose of digoxin. Which factor most significantly affects the volume of distribution (Vd) of digoxin? ā†’ Lean body weight and tissue binding
  4. A patient taking phenytoin for seizures is started on valproic acid. What is the expected net effect on phenytoin? ā†’ Decreased total phenytoin with possible increased free phenytoin levels
  5. A patient with a penicillin allergy (anaphylaxis) requires antibiotic therapy for MRSA. Which agent is most appropriate? ā†’ Vancomycin
  6. Which pharmacokinetic parameter describes the fraction of an administered dose that reaches systemic circulation unchanged? ā†’ Bioavailability (F)
  7. Which phase II metabolic reaction involves conjugation with glucuronic acid? ā†’ Glucuronidation
  8. Which professional attribute is most valued in pharmaceutics within the FPGEE field? ā†’ Accountability and commitment to standards
  9. The Gram stain distinguishes bacteria primarily based on differences in their: ā†’ Cell wall composition
  10. Which antifungal mechanism involves binding to ergosterol and forming pores in the fungal cell membrane? ā†’ Polyenes (amphotericin B)
  11. Which parameter describes the fraction of a drug excreted unchanged in the urine? ā†’ Fraction excreted renally (fe)
  12. Which of the following best describes an 'off-label' use of a medication? ā†’ Use of a drug for an indication, population, or route not approved in its FDA labeling
  13. What is the recommended maximum daily dose of acetaminophen for a healthy adult? ā†’ 4,000 mg
  14. Which of the following is the correct definition of therapeutic equivalence? ā†’ Two drug products that produce the same clinical effect and safety profile
  15. Which property of a drug substance is MOST critical for absorption via passive transcellular diffusion across biological membranes? ā†’ Lipophilicity
  16. When counseling a patient on sublingual nitroglycerin for angina, what is the maximum number of doses to take before calling emergency services? ā†’ 3 doses
  17. Which drug class is associated with development of drug-induced lupus erythematosus? ā†’ Hydralazine and procainamide
  18. A meta-analysis reports an IĀ² statistic of 75%. How should this be interpreted? ā†’ 75% of the variance in effect sizes is due to heterogeneity rather than chance
  19. A patient develops QT prolongation after starting a new antibiotic. Which agent is MOST likely responsible? ā†’ Azithromycin
  20. The Mantoux tuberculin skin test (TST) detects prior exposure to Mycobacterium tuberculosis by measuring which immune response? ā†’ Type IV delayed-type hypersensitivity (DTH)
  21. Which pathophysiological change is responsible for the elevated serum creatinine in pre-renal azotemia? ā†’ Decreased renal perfusion reducing GFR without intrinsic tubular damage
  22. Under the Kefauver-Harris Amendment of 1962, drug manufacturers must demonstrate to the FDA that new drugs are: ā†’ Safe and effective
  23. A patient on warfarin begins taking high-dose vitamin E supplements. What is the expected effect on INR? ā†’ Increased INR due to inhibition of vitamin K-dependent clotting factors
  24. Long chains, or ______________, are how humans store glucose. ā†’ Glycogen
  25. A patient with a sulfa allergy asks about safety of taking hydrochlorothiazide. What is the pharmacist's BEST response? ā†’ Use with caution as cross-reactivity with sulfonamides is possible
  26. What is the most important professional competency for FPGEE certification in pharmacy practice? ā†’ Deep knowledge combined with practical application skills
  27. The Durham-Humphrey Amendment of 1951 established which important distinction in pharmacy practice? ā†’ Distinction between prescription-only (Rx) and over-the-counter (OTC) drugs
  28. A patient with Parkinson's disease taking levodopa/carbidopa develops end-of-dose wearing off. Which add-on agent BEST extends levodopa effect? ā†’ Entacapone (COMT inhibitor)
  29. A patient with renal impairment requires dose adjustment. Which pharmacokinetic parameter is most relevant to assess? ā†’ Renal clearance
  30. Which electrolyte abnormality is MOST commonly associated with loop diuretic therapy? ā†’ Hypokalemia and hypomagnesemia
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