FPGEE Trivia FPGEE Exam 2 — Questions and Answers
Question 1: Which organization administers the FPGEE in the United States?
- NABP (Correct answer)
- ACPE
- ASHP
- BPS
Correct answer: NABP
The National Association of Boards of Pharmacy (NABP) administers the FPGEE.
Question 2: What is the primary mechanism of action of metformin in treating type 2 diabetes?
- Increases insulin secretion
- Decreases hepatic glucose production (Correct answer)
- Blocks glucose absorption in the gut
- Stimulates peripheral glucose uptake via GLUT4
Correct answer: Decreases hepatic glucose production
Metformin primarily works by inhibiting hepatic gluconeogenesis, reducing liver glucose output.
Question 3: Which cytochrome P450 enzyme is responsible for metabolizing approximately 50% of all marketed drugs?
- CYP1A2
- CYP2D6
- CYP3A4 (Correct answer)
- CYP2C9
Correct answer: CYP3A4
CYP3A4 is the most abundant hepatic CYP enzyme and metabolizes roughly half of all drugs.
Question 4: A patient taking warfarin begins a course of fluconazole. What is the expected effect?
- Decreased anticoagulation
- Increased anticoagulation (Correct answer)
- No change in INR
- Reduced fluconazole efficacy
Correct answer: Increased anticoagulation
Fluconazole inhibits CYP2C9, reducing warfarin metabolism and increasing anticoagulant effect.
Question 5: What is the controlled substance schedule for hydrocodone combination products in the US?
- Schedule II (Correct answer)
- Schedule III
- Schedule IV
- Schedule V
Correct answer: Schedule II
Since 2014, all hydrocodone combination products were rescheduled to Schedule II by the DEA.
Question 6: Which electrolyte imbalance is most commonly associated with loop diuretic use?
- Hyperkalemia
- Hyponatremia
- Hypokalemia (Correct answer)
- Hypermagnesemia
Correct answer: Hypokalemia
Loop diuretics inhibit Na-K-2Cl cotransporters, causing potassium wasting and hypokalemia.
Question 7: What is the mechanism of action of statins?
- Inhibit cholesterol absorption in the intestine
- Inhibit HMG-CoA reductase (Correct answer)
- Activate LDL receptors directly
- Block bile acid reabsorption
Correct answer: Inhibit HMG-CoA reductase
Statins competitively inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
FPGEE Trivia FPGEE Exam 2
Which organization administers the FPGEE in the United States?