FPGEE Pharmaceutics 3

Question 1

Which property of a drug substance is MOST critical for absorption via passive transcellular diffusion across biological membranes?

Accepted Answer

Lipophilicity

Answer

Lipophilicity allows drugs to partition into and diffuse across the lipid bilayer via passive transcellular diffusion.

Question 2

According to USP, a 'dilute solution' for oral use contains what maximum concentration of alcohol?

Accepted Answer

10%

Answer

USP defines dilute oral solutions as containing not more than 10% alcohol to limit systemic alcohol exposure.

Question 3

Which type of flow behavior is exhibited by a material whose viscosity decreases under shear stress and does not recover immediately when shear is removed?

Accepted Answer

Thixotropic

Answer

Thixotropic materials show time-dependent shear thinning; viscosity decreases under shear and recovers slowly after shear removal, forming a hysteresis loop.

Question 4

A suppository base that melts at body temperature and is water-soluble is BEST described as:

Accepted Answer

Polyethylene glycol (PEG)

Answer

PEG suppository bases are water-soluble and dissolve in rectal fluids rather than melting, making them suitable for drugs incompatible with fatty bases.

Question 5

In lyophilization (freeze-drying), primary drying removes water by:

Accepted Answer

Sublimation of ice under reduced pressure

Answer

Primary drying in lyophilization removes frozen water by sublimation under vacuum, bypassing the liquid phase.

FPGEE Exam Practice Test

FPGEE Exam Practice Test

FPGEE Pharmaceutics 3