FPGEE Pharmaceutics 3

Question 1

Which property of a drug substance is MOST critical for absorption via passive transcellular diffusion across biological membranes?

Accepted Answer

Lipophilicity

Answer

High molecular weight

Answer

Ionization at physiological pH

Answer

High aqueous solubility only

Question 2

According to USP, a 'dilute solution' for oral use contains what maximum concentration of alcohol?

Accepted Answer

10%

Answer

5%

Answer

15%

Answer

20%

Question 3

Which type of flow behavior is exhibited by a material whose viscosity decreases under shear stress and does not recover immediately when shear is removed?

Accepted Answer

Thixotropic

Answer

Pseudoplastic

Answer

Dilatant

Answer

Plastic (Bingham)

Question 4

A suppository base that melts at body temperature and is water-soluble is BEST described as:

Accepted Answer

Polyethylene glycol (PEG)

Answer

Cocoa butter

Answer

Hydrogenated vegetable oil

Answer

Witepsol

Question 5

In lyophilization (freeze-drying), primary drying removes water by:

Accepted Answer

Sublimation of ice under reduced pressure

Answer

Evaporation at elevated temperature

Answer

Dissolution in organic solvents

Answer

Adsorption onto excipients

Question 6

Which parameter is used to quantify the drug content uniformity of solid dosage forms according to USP?

Accepted Answer

Relative standard deviation (RSD)

Answer

Loss on drying

Answer

Disintegration time

Answer

Angle of repose

Question 7

Hydrophilic-lipophilic balance (HLB) values between 8 and 18 are MOST suitable for:

Accepted Answer

O/W emulsifiers

Answer

W/O emulsifiers

Answer

Solubilizing agents

Answer

Wetting agents