CT CT Gynecologic Cytology 2

Question 1

On a Pap test, small dark cells with scant cytoplasm and nuclear molding that are shed in sheets from the lower uterine segment are most consistent with which entity?

Accepted Answer

Endometrial stromal cells from the lower uterine segment

Answer

Lower uterine segment stromal cells appear as tight clusters of small dark cells with scant cytoplasm and may mimic high-grade lesions but lack atypia.

Question 2

Which cytomorphologic feature best distinguishes endocervical adenocarcinoma in situ (AIS) from reactive endocervical cells on a Pap test?

Accepted Answer

Nuclear feathering, pseudostratification, and apoptotic bodies

Answer

AIS characteristically shows nuclear feathering (cells projecting from sheet edges), pseudostratification, hyperchromasia, and apoptosis absent in reactive changes.

Question 3

A Pap test from a 55-year-old woman demonstrates large cells with abundant granular cytoplasm, prominent nucleoli, and nuclear enlargement in small clusters. What is the most likely diagnosis?

Accepted Answer

Endometrial adenocarcinoma

Answer

Endometrial adenocarcinoma cells typically appear in small clusters with nuclear enlargement, prominent nucleoli, and variable cytoplasm, often with vacuolization.

Question 4

According to the 2019 ASCCP guidelines, what is the preferred management for a patient with an ASC-H Pap result?

Accepted Answer

Colposcopy

Answer

ASC-H (atypical squamous cells, cannot exclude HSIL) carries a higher risk of underlying CIN 2/3 and therefore warrants immediate colposcopic evaluation.

Question 5

Which liquid-based cytology preparation method uses a density gradient centrifugation technique that results in a thin monolayer deposit?

Accepted Answer

SurePath (BD)

Answer

SurePath uses a density gradient sedimentation process that settles cells onto the slide in a monolayer, while ThinPrep uses a filter-transfer method.

CT - Certified Cytotechnologist Practice Test

CT - Certified Cytotechnologist Practice Test

CT CT Gynecologic Cytology 2