CT CT Gynecologic Cytology

Question 1

According to The Bethesda System, which category is used for Pap test results that cannot be clearly classified as normal or abnormal?

Accepted Answer

Atypical squamous cells of undetermined significance (ASC-US)

Answer

Low-grade squamous intraepithelial lesion (LSIL)

Answer

High-grade squamous intraepithelial lesion (HSIL)

Answer

Squamous cell carcinoma

Question 2

Which cellular feature is the hallmark of koilocytic atypia, indicating HPV cytopathic effect in cervical specimens?

Accepted Answer

Perinuclear cytoplasmic clearing (halo) with nuclear irregularity

Answer

Nuclear hyperchromasia with dense cytoplasm

Answer

Single cell necrosis with karyorrhexis

Answer

Intracytoplasmic mucin vacuoles

Question 3

A ThinPrep Pap test from a 35-year-old woman shows cells with a high nuclear-to-cytoplasmic ratio, hyperchromatic nuclei, irregular nuclear membranes, and coarse chromatin. What is the most appropriate Bethesda diagnosis?

Accepted Answer

HSIL

Answer

ASC-US

Answer

LSIL

Answer

Atypical glandular cells (AGC)

Question 4

Which transformation zone component must be present for a cervical Pap test to be considered adequate for evaluation by The Bethesda System?

Accepted Answer

Endocervical or squamous metaplastic cells

Answer

Parabasal cells

Answer

Histiocytes

Answer

Endometrial cells

Question 5

In postmenopausal women, the presence of which finding on a Pap test typically warrants clinical correlation due to potential endometrial pathology?

Accepted Answer

Exfoliated endometrial cells after day 12

Answer

Lactobacillus-dominant flora

Answer

Atrophic epithelial cells

Answer

Navicular cells

Question 6

Which organism, identified on Pap testing, presents as 'shift in flora' and is associated with bacterial vaginosis (BV)?

Accepted Answer

Gardnerella/Mobiluncus causing 'clue cells'

Answer

Trichomonas vaginalis

Answer

Candida species

Answer

Actinomyces-like organisms