Anatomy Exam Histology of Connective Tissues 2

Question 1

Which glycosaminoglycan is unique to cartilage extracellular matrix?

Accepted Answer

Chondroitin sulfate

Answer

Chondroitin sulfate is the predominant glycosaminoglycan in cartilage, forming large proteoglycan aggregates with aggrecan.

Question 2

Mast cells in connective tissue are derived from which precursor?

Accepted Answer

Myeloid progenitors in bone marrow

Answer

Mast cells originate from myeloid progenitor cells in bone marrow and mature in connective tissues.

Question 3

Which type of collagen forms anchoring fibrils at the dermal-epidermal junction?

Accepted Answer

Type VII

Answer

Type VII collagen forms anchoring fibrils that connect the basement membrane to the underlying dermis.

Question 4

Elastic fibers in connective tissue are composed primarily of which protein core?

Accepted Answer

Elastin

Answer

Elastic fibers consist of an elastin core surrounded by a meshwork of fibrillin microfibrils.

Question 5

Which connective tissue cell type secretes heparin and histamine?

Accepted Answer

Mast cells

Answer

Mast cells store heparin and histamine in their cytoplasmic granules, releasing them during degranulation.

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