AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 3

Question 1

A 30-year-old of Mediterranean descent has a haemoglobin of 85 g/L, MCV of 62 fL, normal iron studies, and elevated HbA2 on electrophoresis. What is the most likely diagnosis?

Accepted Answer

Beta-thalassaemia trait

Answer

Beta-thalassaemia trait presents with mild microcytic anaemia, normal or elevated HbA2 (>3.5%) on haemoglobin electrophoresis, and normal iron studies.

Question 2

A patient undergoes a bone marrow biopsy showing hypercellular marrow with >20% blasts. Flow cytometry reveals CD13, CD33, and MPO positivity. What is the diagnosis?

Accepted Answer

Acute myeloid leukaemia (AML)

Answer

AML is characterised by ≥20% myeloid blasts in the bone marrow with expression of myeloid markers (CD13, CD33) and myeloperoxidase (MPO).

Question 3

Which tumour marker is most useful for monitoring treatment response in colorectal cancer?

Accepted Answer

CEA (carcinoembryonic antigen)

Answer

CEA is the primary tumour marker for monitoring recurrence and treatment response in colorectal cancer.

Question 4

A 55-year-old man presents with urinary hesitancy, a PSA of 18 ng/mL, and a hard irregular prostate on digital rectal exam. Biopsy shows adenocarcinoma, Gleason score 7. What is the initial management for localised disease?

Accepted Answer

Radical prostatectomy or external beam radiotherapy

Answer

Intermediate-risk localised prostate cancer (Gleason 7, elevated PSA) is treated with curative intent via radical prostatectomy or external beam radiotherapy.

Question 5

A 50-year-old woman post-chemotherapy presents with fever (38.5°C) and an absolute neutrophil count of 0.3 × 10⁹/L. What is the most appropriate immediate management?

Accepted Answer

Start empirical broad-spectrum intravenous antibiotics immediately

Answer

Febrile neutropenia is a medical emergency; empirical broad-spectrum IV antibiotics (e.g., piperacillin-tazobactam) must be started immediately without waiting for culture results.

AMC MCQ Practice Test

AMC MCQ Practice Test

AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 3