AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 3

Question 1

A 30-year-old of Mediterranean descent has a haemoglobin of 85 g/L, MCV of 62 fL, normal iron studies, and elevated HbA2 on electrophoresis. What is the most likely diagnosis?

Accepted Answer

Beta-thalassaemia trait

Answer

Iron deficiency anaemia

Answer

Anaemia of chronic disease

Answer

Lead poisoning

Question 2

A patient undergoes a bone marrow biopsy showing hypercellular marrow with >20% blasts. Flow cytometry reveals CD13, CD33, and MPO positivity. What is the diagnosis?

Accepted Answer

Acute myeloid leukaemia (AML)

Answer

Acute lymphoblastic leukaemia (ALL)

Answer

Chronic myeloid leukaemia (CML)

Answer

Myelodysplastic syndrome

Question 3

Which tumour marker is most useful for monitoring treatment response in colorectal cancer?

Accepted Answer

CEA (carcinoembryonic antigen)

Answer

CA 125

Answer

PSA

Answer

AFP

Question 4

A 55-year-old man presents with urinary hesitancy, a PSA of 18 ng/mL, and a hard irregular prostate on digital rectal exam. Biopsy shows adenocarcinoma, Gleason score 7. What is the initial management for localised disease?

Accepted Answer

Radical prostatectomy or external beam radiotherapy

Answer

Watchful waiting only

Answer

Immediate androgen deprivation therapy (ADT)

Answer

Chemotherapy with docetaxel

Question 5

A 50-year-old woman post-chemotherapy presents with fever (38.5°C) and an absolute neutrophil count of 0.3 × 10⁹/L. What is the most appropriate immediate management?

Accepted Answer

Start empirical broad-spectrum intravenous antibiotics immediately

Answer

Await blood culture results before starting antibiotics

Answer

Administer G-CSF alone

Answer

Oral ciprofloxacin as outpatient

Question 6

Which drug causes a dose-dependent cardiomyopathy that limits its cumulative lifetime dose?

Accepted Answer

Doxorubicin (anthracycline)

Answer

Cyclophosphamide

Answer

Vincristine

Answer

Methotrexate