Which mechanism does Staphylococcus aureus use to confer resistance to beta-lactam antibiotics including methicillin?
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A
Production of beta-lactamase that hydrolyzes the antibiotic
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B
Expression of altered penicillin-binding protein PBP2a encoded by mecA
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C
Active efflux of the antibiotic via MexAB-OprM pump
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D
Reduced outer membrane permeability preventing drug entry