Physician Assistant Genitourinary and Renal System Disorders 3

Question 1

A 6-year-old develops cola-colored urine, periorbital edema, and hypertension 2 weeks after pharyngitis. Which lab is expected?

Accepted Answer

Low C3 complement

Answer

Post-streptococcal glomerulonephritis causes transiently low C3 that normalizes within 6-8 weeks.

Question 2

A 22-year-old man has gross hematuria 1-2 days after an upper respiratory infection. What is the most likely diagnosis?

Accepted Answer

IgA nephropathy

Answer

IgA nephropathy classically causes synpharyngitic hematuria within days of a mucosal infection.

Question 3

A patient has hemoptysis and rapidly progressive glomerulonephritis with linear IgG deposits on immunofluorescence. What is the diagnosis?

Accepted Answer

Goodpasture syndrome

Answer

Linear IgG deposition along the GBM is characteristic of anti-GBM (Goodpasture) disease.

Question 4

Which nephrotic syndrome is most commonly associated with HIV and heroin use and has a predilection for Black patients?

Accepted Answer

Focal segmental glomerulosclerosis

Answer

FSGS (collapsing variant in HIV) is associated with HIV, heroin, obesity, and APOL1 variants.

Question 5

An adult with nephrotic syndrome and anti-PLA2R antibodies most likely has which condition?

Accepted Answer

Membranous nephropathy

Answer

Anti-phospholipase A2 receptor antibodies are found in most cases of primary membranous nephropathy.

Physician Assistant Practice Test