Parkinson's Knowledge 3

Question 1

Which brain region is most severely affected in the early stages of Parkinson's disease?

Accepted Answer

Substantia nigra pars compacta

Answer

The substantia nigra pars compacta, which produces dopamine, is the region most affected early in Parkinson's disease.

Question 2

What is the 'on-off' phenomenon in Parkinson's disease?

Accepted Answer

Fluctuations between periods of good motor control and poor motor control

Answer

The 'on-off' phenomenon describes unpredictable motor fluctuations where medication effectiveness varies, causing periods of good control ('on') and poor control ('off').

Question 3

Which of the following genes is associated with autosomal dominant Parkinson's disease?

Accepted Answer

LRRK2 (PARK8)

Answer

Mutations in LRRK2 are the most common known genetic cause of autosomal dominant Parkinson's disease.

Question 4

What does the term 'wearing off' describe in the context of Parkinson's medication?

Accepted Answer

Return of symptoms before the next scheduled dose

Answer

'Wearing off' occurs when levodopa's benefit diminishes before the next dose is due, causing symptoms to return.

Question 5

Which occupational therapy goal is most relevant for a patient with Parkinson's disease experiencing freezing of gait?

Accepted Answer

Using visual cues or rhythmic auditory signals to initiate movement

Answer

Visual floor cues (e.g., tape lines) and auditory rhythms help patients with freezing of gait overcome motor blocks.

Parkinson's Practice Test

Parkinson's Practice Test

Parkinson's Knowledge 3