AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 2

Question 1

A 65-year-old presents with lymphocytosis (lymphocyte count 80 × 10⁹/L), smudge cells on peripheral blood film, and painless generalised lymphadenopathy. What is the most likely diagnosis?

Accepted Answer

Chronic lymphocytic leukaemia

Answer

Chronic lymphocytic leukaemia (CLL) presents with marked lymphocytosis, smudge cells on blood film, and indolent lymphadenopathy in older adults.

Question 2

A 55-year-old patient develops disseminated intravascular coagulation (DIC). Laboratory findings include prolonged PT/APTT, low fibrinogen, elevated D-dimer, and thrombocytopenia. What is the primary treatment approach?

Accepted Answer

Treat the underlying cause

Answer

The cornerstone of DIC management is treating the underlying trigger (e.g., sepsis, malignancy), as supportive blood products alone without addressing the cause will not resolve DIC.

Question 3

A breast cancer patient is found to have HER2 gene amplification. Which targeted therapy specifically targets this receptor?

Accepted Answer

Trastuzumab

Answer

Trastuzumab (Herceptin) is a monoclonal antibody targeting HER2 (ErbB2), used in HER2-positive breast and gastric cancers.

Question 4

A patient with sickle cell disease presents in vasoocclusive crisis with severe pain. Which medication reduces the frequency of crises by increasing foetal haemoglobin (HbF)?

Accepted Answer

Hydroxyurea

Answer

Hydroxyurea increases production of foetal haemoglobin (HbF), which inhibits HbS polymerisation and reduces vasoocclusive crises in sickle cell disease.

Question 5

A 40-year-old with deep vein thrombosis is found to have Factor V Leiden mutation. What does this mutation cause?

Accepted Answer

Resistance to activated protein C (APC resistance)

Answer

Factor V Leiden mutation results in a factor V that is resistant to cleavage by activated protein C, predisposing to venous thromboembolism.

AMC MCQ Practice Test

AMC MCQ Practice Test

AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 2