AMC MCQ AMC MCQ - Australian Medical Council Multiple Choice Questions Haematology and Oncology Questions and Answers 2

Question 1

A 65-year-old presents with lymphocytosis (lymphocyte count 80 × 10⁹/L), smudge cells on peripheral blood film, and painless generalised lymphadenopathy. What is the most likely diagnosis?

Accepted Answer

Chronic lymphocytic leukaemia

Answer

Acute lymphoblastic leukaemia

Answer

Hairy cell leukaemia

Answer

T-cell lymphoma

Question 2

A 55-year-old patient develops disseminated intravascular coagulation (DIC). Laboratory findings include prolonged PT/APTT, low fibrinogen, elevated D-dimer, and thrombocytopenia. What is the primary treatment approach?

Accepted Answer

Treat the underlying cause

Answer

Administer heparin to prevent further clotting

Answer

Give fresh frozen plasma alone

Answer

Administer platelet transfusion alone

Question 3

A breast cancer patient is found to have HER2 gene amplification. Which targeted therapy specifically targets this receptor?

Accepted Answer

Trastuzumab

Answer

Bevacizumab

Answer

Cetuximab

Answer

Rituximab

Question 4

A patient with sickle cell disease presents in vasoocclusive crisis with severe pain. Which medication reduces the frequency of crises by increasing foetal haemoglobin (HbF)?

Accepted Answer

Hydroxyurea

Answer

Deferoxamine

Answer

Erythropoietin

Answer

Penicillin V

Question 5

A 40-year-old with deep vein thrombosis is found to have Factor V Leiden mutation. What does this mutation cause?

Accepted Answer

Resistance to activated protein C (APC resistance)

Answer

Reduced thrombin generation

Answer

Deficiency of antithrombin III

Answer

Overproduction of plasminogen

Question 6

A 68-year-old presents with splenomegaly, elevated RBC count, haematocrit of 58%, and JAK2 V617F mutation. What is the diagnosis?

Accepted Answer

Polycythaemia vera

Answer

Secondary polycythaemia

Answer

Essential thrombocythaemia

Answer

Myelofibrosis

A 65-year-old presents with lymphocytosis (lymphocyte count 80 × 10⁹/L), smudge cells on peripheral blood film, and painless generalised lymphadenopathy.What is the most likely diagnosis?

A 65-year-old presents with lymphocytosis (lymphocyte count 80 × 10⁹/L), smudge cells on peripheral blood film, and painless generalised lymphadenopathy.
What is the most likely diagnosis?