OCN Oncology Pharmacology 3

Question 1

Immune-related adverse events (irAEs) from checkpoint inhibitors most commonly affect which organ systems?

Accepted Answer

Skin, GI tract, liver, and endocrine glands

Answer

Checkpoint inhibitors cause autoimmune-like reactions most frequently in skin (rash), gut (colitis), liver (hepatitis), and endocrine organs (thyroiditis).

Question 2

PARP inhibitors such as olaparib are most effective in cancers with defects in which pathway?

Accepted Answer

Homologous recombination repair (BRCA1/2 mutations)

Answer

PARP inhibitors exploit synthetic lethality in BRCA-mutated cells that cannot repair DNA through homologous recombination, leading to cancer cell death.

Question 3

CAR-T cell therapy requires which critical patient preparation step?

Accepted Answer

Lymphodepleting chemotherapy before infusion

Answer

Lymphodepleting chemotherapy (conditioning) before CAR-T infusion removes endogenous lymphocytes to create space for the engineered T-cells to expand.

Question 4

Cytokine release syndrome (CRS) is a potentially life-threatening complication most associated with which therapies?

Accepted Answer

CAR-T cell therapy and bispecific antibodies

Answer

CRS is a systemic inflammatory response caused by massive cytokine release when immune cells are activated by CAR-T cell therapy or bispecific antibodies.

Question 5

Which agent is used as antidote or reversal for severe methotrexate toxicity when leucovorin is insufficient?

Accepted Answer

Glucarpidase (carboxypeptidase G2)

Answer

Glucarpidase rapidly converts methotrexate to inactive metabolites in the plasma, used when methotrexate levels remain dangerously high despite leucovorin rescue.

OCN Exam Practice Test

OCN Exam Practice Test

OCN Oncology Pharmacology 3