OCN Oncology Pharmacology

Question 1

Targeted therapy with imatinib (Gleevec) works by inhibiting which specific molecular target?

Accepted Answer

BCR-ABL tyrosine kinase

Answer

HER2 receptor

Answer

VEGF receptor

Answer

EGFR receptor

Question 2

Trastuzumab (Herceptin) is indicated for cancers that overexpress which receptor?

Accepted Answer

HER2 (human epidermal growth factor receptor 2)

Answer

Estrogen receptor (ER)

Answer

Progesterone receptor (PR)

Answer

Androgen receptor (AR)

Question 3

Which drug class inhibits the mammalian target of rapamycin (mTOR) pathway in cancer treatment?

Accepted Answer

Everolimus and temsirolimus

Answer

Erlotinib and gefitinib

Answer

Bevacizumab and ramucirumab

Answer

Ipilimumab and nivolumab

Question 4

Immune checkpoint inhibitors such as nivolumab work by blocking which protein to restore T-cell function?

Accepted Answer

PD-1 (programmed death-1)

Answer

CTLA-4 only

Answer

LAG-3 only

Answer

HER2

Question 5

EGFR inhibitors such as erlotinib are most effective in NSCLC patients who have which characteristic?

Accepted Answer

Activating EGFR mutation

Answer

KRAS mutation

Answer

ALK rearrangement

Answer

PD-L1 negative status

Question 6

Bevacizumab (Avastin) targets tumor angiogenesis by inhibiting which growth factor?

Accepted Answer

Vascular endothelial growth factor (VEGF)

Answer

Fibroblast growth factor (FGF)

Answer

Platelet-derived growth factor (PDGF)

Answer

Epidermal growth factor (EGF)