OCC OCC Pharmacology & Therapeutics

Question 1

A DO prescribes a patient metformin for type 2 diabetes. Which mechanism of action best describes metformin?

Accepted Answer

Decreases hepatic glucose production and improves insulin sensitivity

Answer

Metformin primarily works by activating AMPK to reduce hepatic gluconeogenesis and increase peripheral insulin sensitivity.

Question 2

Which drug interaction results in increased risk of bleeding when warfarin is combined with aspirin?

Accepted Answer

Additive anticoagulant and antiplatelet effect increases hemorrhagic risk

Answer

Warfarin inhibits clotting factors while aspirin inhibits platelet aggregation — combined use additively increases bleeding risk.

Question 3

A patient on a fluoroquinolone antibiotic develops tendon pain. Which tendon is most commonly affected?

Accepted Answer

Achilles tendon

Answer

Fluoroquinolone antibiotics carry a black box warning for Achilles tendon rupture, with the Achilles being the most commonly affected tendon.

Question 4

Which class of antihypertensive medication is contraindicated in bilateral renal artery stenosis?

Accepted Answer

ACE inhibitors and ARBs

Answer

ACE inhibitors and ARBs reduce efferent arteriolar tone, which drops GFR critically in bilateral renal artery stenosis where GFR depends on angiotensin II.

Question 5

Which Schedule II controlled substance requires a written or electronic prescription and cannot be refilled?

Accepted Answer

Oxycodone

Answer

Oxycodone is Schedule II; prescriptions cannot be refilled and require a new written or e-prescribe for each fill.

OCC - Osteopathic Continuous Certification Practice Test

OCC - Osteopathic Continuous Certification Practice Test

OCC OCC Pharmacology & Therapeutics