OCC OCC Pharmacology & Therapeutics 3

Question 1

A patient develops a dry cough after starting lisinopril for hypertension. What is the best alternative medication?

Accepted Answer

Angiotensin receptor blocker (ARB) such as losartan

Answer

ACE inhibitor-induced cough is a class effect caused by bradykinin accumulation; switching to an ARB (which doesn't affect bradykinin) eliminates the cough.

Question 2

Which vaccine is CONTRAINDICATED in immunocompromised patients due to being a live attenuated vaccine?

Accepted Answer

MMR (measles, mumps, rubella)

Answer

MMR is a live attenuated vaccine and can cause disseminated vaccine-strain infection in immunocompromised patients.

Question 3

Which medication class is first-line for chronic stable angina due to its ability to reduce heart rate, contractility, and myocardial oxygen demand?

Accepted Answer

Beta-blockers

Answer

Beta-blockers are first-line for chronic stable angina because they reduce heart rate and contractility, lowering myocardial oxygen demand and decreasing anginal episodes.

Question 4

A patient with gout has frequent attacks and is started on allopurinol. What is the mechanism of allopurinol?

Accepted Answer

Inhibits xanthine oxidase to reduce uric acid production

Answer

Allopurinol is a xanthine oxidase inhibitor that blocks the conversion of hypoxanthine and xanthine to uric acid, reducing uric acid production.

Question 5

Which anticoagulant requires no routine lab monitoring and directly inhibits thrombin (Factor IIa)?

Accepted Answer

Dabigatran (Pradaxa)

Answer

Dabigatran is a direct thrombin (Factor IIa) inhibitor that provides predictable anticoagulation without routine INR monitoring.

OCC - Osteopathic Continuous Certification Practice Test

OCC - Osteopathic Continuous Certification Practice Test

OCC OCC Pharmacology & Therapeutics 3