OCC OCC Clinical Trials & Evidence-Based Practice 2

Question 1

Which study design provides the HIGHEST level of evidence for evaluating the effectiveness of a new chemotherapy regimen?

Accepted Answer

Randomized controlled trial (RCT)

Answer

The randomized controlled trial is the gold standard study design for establishing causal efficacy by minimizing bias through randomization and controlled comparison.

Question 2

A patient's oncologist recommends a treatment listed as Category 1 in the NCCN Guidelines. What does this designation mean?

Accepted Answer

High-level evidence with uniform consensus that the recommendation is appropriate

Answer

NCCN Category 1 designations indicate high-level evidence (usually from RCTs) with uniform consensus among NCCN panel members supporting the recommendation.

Question 3

The oncology nurse is reviewing a study that reports a hazard ratio (HR) of 0.65 with a 95% CI of 0.50-0.85 for a new drug versus placebo. What does this mean?

Accepted Answer

The new drug reduces the risk of the event by 35%, and this is statistically significant

Answer

An HR of 0.65 means a 35% reduction in the hazard (risk) of the event; since the 95% CI (0.50-0.85) does not cross 1.0, the result is statistically significant.

Question 4

Which quality improvement model is MOST commonly used in oncology nursing practice to implement and evaluate evidence-based changes?

Accepted Answer

PDSA (Plan-Do-Study-Act) cycle

Answer

The PDSA cycle is the most widely used quality improvement model in nursing and oncology practice for iterative, evidence-based practice change.

Question 5

A nurse wants to find the best evidence for managing chemotherapy-induced nausea. Which resource provides the MOST credible, peer-reviewed clinical practice guidelines?

Accepted Answer

ASCO, ONS, or NCCN clinical practice guidelines

Answer

Professional organization guidelines from ASCO, ONS, and NCCN are developed through systematic evidence review and expert consensus, providing the most credible clinical practice guidance.

(OCC) Oncology Chemotherapy Certification Practice Test

(OCC) Oncology Chemotherapy Certification Practice Test

OCC OCC Clinical Trials & Evidence-Based Practice 2