OCC Study Guide 2026
Everything you need to pass the OCC exam in one place: the exam format, every topic to study, real practice questions with explanations, flashcards, and full-length practice tests. Free, no sign-up needed.
📋 OCC Exam Format at a Glance
📚 OCC Topics to Study (38)
✍️ Sample OCC Questions & Answers
1. When priming IV tubing for a chemotherapy infusion, which technique best minimizes occupational exposure?
Priming IV tubing with a plain compatible IV solution before connecting the chemotherapy bag prevents drug exposure during the priming process.
2. A nurse is monitoring a patient for capecitabine-related hand-foot syndrome (palmar-plantar erythrodysesthesia). Which Grade 3 finding warrants dose modification?
Grade 3 hand-foot syndrome includes blistering, ulceration, or severe pain that prevents normal activity and requires chemotherapy dose reduction or interruption.
3. A nurse learns that a patient's chemotherapy order contains a dose that exceeds safe parameters according to the prescribing information. Before administering, the nurse should:
Nurses have an independent duty to verify safe medication dosing and must clarify unsafe orders before administration.
4. The nurse's role in advocating for systemic change in chemotherapy safety policy is BEST supported by which professional organization?
The ONS provides oncology nurses with advocacy resources, professional standards, and policy positions specific to chemotherapy safety.
5. What is the first procedural step in manufacturing autologous CAR-T cell therapy for a patient?
Leukapheresis to collect the patient's own T cells is the first manufacturing step; these cells are then genetically engineered to express the chimeric antigen receptor.
6. Which statement best describes the mechanism by which trastuzumab (Herceptin) enhances chemotherapy efficacy in HER2-positive breast cancer?
Trastuzumab binds HER2 domain IV, inhibiting downstream proliferation signaling and mediating antibody-dependent cellular cytotoxicity (ADCC) against HER2-overexpressing cells.