OCC Study Guide 2026
Everything you need to pass the OCC exam in one place: the exam format, every topic to study, real practice questions with explanations, flashcards, and full-length practice tests. Free, no sign-up needed.
📋 OCC Exam Format at a Glance
📚 OCC Topics to Study (22)
✍️ Sample OCC Questions & Answers
1. What is the first procedural step in manufacturing autologous CAR-T cell therapy for a patient?
Leukapheresis to collect the patient's own T cells is the first manufacturing step; these cells are then genetically engineered to express the chimeric antigen receptor.
2. A patient with a new PICC line develops sudden onset of dyspnea, hypotension, and a 'sucking' sound during catheter manipulation. What complication is occurring?
Air embolism can occur during open central catheter manipulation and presents with sudden dyspnea, hypotension, and a mill-wheel murmur or sucking sound.
3. A nurse notes an unexpected serious adverse event in a patient on a clinical trial. What is the MOST important immediate action?
Serious adverse events must be documented, immediately reported to the PI, and captured in the adverse event reporting system per the protocol's safety monitoring plan.
4. A patient's oncologist recommends a treatment listed as Category 1 in the NCCN Guidelines. What does this designation mean?
NCCN Category 1 designations indicate high-level evidence (usually from RCTs) with uniform consensus among NCCN panel members supporting the recommendation.
5. Atezolizumab differs from pembrolizumab and nivolumab in that it targets which molecule?
Atezolizumab targets PD-L1 (the ligand) rather than PD-1 (the receptor), blocking the interaction from the antigen-presenting or tumor cell side.
6. Which factor MOST increases a patient's risk for chemotherapy extravasation injury?
Fragile veins with multiple prior cannulation sites have compromised integrity, significantly increasing the risk of extravasation during chemotherapy infusion.