OCC Pharmacology of Chemotherapeutic Agents

Question 1

Which class of chemotherapeutic agents is known to cause cardiotoxicity as a major side effect?

Accepted Answer

Anthracyclines

Answer

Alkylating agents

Answer

Antimetabolites

Answer

Topoisomerase inhibitors

Question 2

Which chemotherapeutic drug is associated with hemorrhagic cystitis?

Accepted Answer

Cyclophosphamide

Answer

Methotrexate

Answer

Cisplatin

Answer

Fluorouracil

Question 3

What is the primary mechanism of action of antimetabolites in chemotherapy?

Accepted Answer

Mimic nucleotides to inhibit DNA synthesis

Answer

Disrupt microtubule formation

Answer

Cause DNA cross-linking

Answer

Inhibit angiogenesis

Question 4

Why is mesna co-administered with ifosfamide or cyclophosphamide?

Accepted Answer

To protect the bladder from toxicity

Answer

To reduce nausea and vomiting

Answer

To enhance cytotoxic effects

Answer

To prevent cardiotoxicity

Question 5

Which chemotherapeutic agent is commonly linked with nephrotoxicity requiring pre- and post-hydration protocols?

Accepted Answer

Cisplatin

Answer

Vincristine

Answer

Etoposide

Answer

Paclitaxel

Question 6

What is the primary dose-limiting toxicity of vincristine?

Accepted Answer

Neurotoxicity

Answer

Myelosuppression

Answer

Cardiotoxicity

Answer

Nephrotoxicity